Career
University of New South Wales: The Second-Line Study

Project Timeline

March 2010 – March 2013

WHO-recommended second-line antiretroviral therapy (ART) of a pharmacologically enhanced (boosted) protease inhibitor plus nucleoside or nucleotide reverse transcriptase inhibitors (NtRTIs) might be compromised by resistance. Results of the 96 week SECOND-LINE randomised trial showed that NtRTI-sparing ART with ritonavir-boosted lopinavir and raltegravir (raltegravir-group) provided non-inferior efficacy to ritonavir-boosted lopinavir and two or three NtRTIs (NtRTI-group) in participants with virological failure composed of a first-line regimen of a non-nucleoside reverse transcriptase inhibitor plus two NtRTIs. We report the relation of baseline virological resistance with virological failure and emergent resistance on study.

External Links

Baseline HIV-1 resistance, virological outcomes, and emergent resistance in the SECOND-LINE trial: an exploratory analysis – PubMed

Events

Other Completed Projects

Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia: Correlations between clinical, phenotypic, genotypic characteristics and mortality in a tertiary teaching hospital in Malaysia
Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is a serious infection that can result in significant morbidity and mortality. A retrospective cohort study was conducted to determine the predictors of mortality in...
A Novel Community Healthcare Service Delivery Model For Fishermen Who Use Drugs In Kuantan, Pahang: An Implementation Science Research
It has been estimated that there are 170,000 people who inject drugs (PWID) in Malaysia. HIV prevalence among PWID in Malaysia ranges from 25 % to 45 %. Further, people...
Malaysian AIDS Council: Baseline Assessment for Community Action on Harm Reduction
Community Action on Harm Reduction project, implemented by the Alliance with support of the Ministry of Foreign Affairs of the government of the Netherlands (as a project number 23389), started...