Harapan I

Project Timeline

1 November 2009 – 31 December 2017

Project HARAPAN was a 2×2 randomized, controlled trial of a prison-based, pre-release methadone program and an evidence-based behavioral intervention (HHRP) for HIV-infected, opioid dependent prisoners in Malaysia. Participants were randomized to one of four study arms: methadone only; HHRP only; methadone and HHRP; control/standard of care. Participants were interviewed at baseline, day of release from prison, and then monthly for 12 months post-release. Primary outcomes included retention in HIV care, retention in substance dependence treatment, time to relapse to drugs, and time to re-incarceration.

External Links


Other Clinical Research

Strategic Timing of Anti-Retroviral Treatment (START Study)
The START trial was designed to address the question: In HIV-1 (subsequently referred to as HIV) infected asymptomatic participants with a CD4+ count greater than 500 cells/mm3, is immediate use...
Making Drug Treatment Work: Opportunities and Challenges Towards an Evidence and Rights-Based Approach
Compulsory drug detention centers (CDDCs) are common throughout Asia. However, medical treatments for substance use disorders, such as opioid agonist treatment (OAT), are generally unavailable in these settings. In this...
Dolutegravir and Darunavir Evaluation in Adults Failing Therapy (D²EFT)
First-line antiretroviral regimens are safe, effective and easily administered (one pill taken once daily). Even so, the annual failure rate is around 10-15% of treated patients. Second-line regimens have a...